Yuting (Jasmine) Qiu Email: ytqiu.jlu AT gmail DOT com Phone: 8578003611 CV | Linkedin | Google Scholar Ph.D. in Chemical Engineering. Master of Public Health from Harvard T.H. Chan School of Public Health. Over ten years of experience in cell therapy and tissue engineering. Skills in applying economic, legal, and political analysis to the design, implementation, and evaluation of health care and public health policies. Upstream experience from Bristol-Myers Squibb, MA; Leader of in-vitro group in Catabasis, Cambridge; Senior scientist of Cancer Biology and Immunology in Crown Bioscience. Healthcare data scientist(projects management) experiences of Boston Children Hospital/Harvard Medical School and MIT Media Lab. Two Healthcare VC work experiences from DT Capital Partners and Shengshan Capital. Give presentations at national and international conference. Authorized seven journal publications as first author. Able to lead external projects with minimal supervision. Highly self-motivated individual with ability to efficiently manage multiple tasks and good at literature reading and be able to creatively resolve different challenges.

Biography

Dr. Qiu received the Ph.D degree in Chemical Engineering from Northeastern University. She worked with Prof. Su in the Su Nanomaterials and Nanomedicine Group. Before that she received her master degree in the Department of chemistry and chemical biology department, Northeastern University, USA, in Jan. 2015, Bachelor’s Degree in Engineering from School of Chemistry, Bachelor’s Degree in Actuarial Sciences from College of Mathematics, Jilin University, China, in Jul. 2013. From August. 2014, she was working with her Ph.D. advisor Prof. Su on Nanoparticle focused/enhanced X-ray radiation therapy , Precision medicines with 3D microtissue and Single cell array based DNA damage assay, and Multiplexed biomarker detection, Northeastern University, Boston, MA. Dr. Qiu also received Master of Public Health from Harvard School of Public Health in May 2018 and earned Master of Fine Arts from Berklee College of Music Dec. 2019. She has successfully finished several internships/coops in Harvard Medical School, pharmaceutical companies including Catabasis in Cambridge, MA and Bristol Myers Squibb, Cambridge, MA. She was a visiting student (Jan. 2010 ~ Jan. 2011) in School of Material Science and Engineering, Nanyang Technological University, Singapore. She worked as senior scientist in Crown Bioscience, taking multiple tasks like characterization and contamination detection of cell lines and organoids by barcode deep NGS sequencing, establishing tumour organoid biobank using Patient-Derived Xenograft (PDX) Library to enable drug discovery and translational research, creating matched in vivo/in vitro patient-derived model pairs of PDX and PDX-Derived organoids for cancer pharmacology research from May. 2020 to Aug. 2021.

Education

Master of Fine Arts Academic Departments, Berklee College of Music Boston, MA, USA, Dec 2019 Master of Public Health (Part-Time) Harvard T.H. Chan School of Public Health, Harvard University Boston, MA, USA, May 2018 Ph.D. in Chemical Engineering College of Chemical Engineering, Northeastern University Boston, USA, Jan. 2015 ~ Jul. 2018 M.S. Degree in Chemistry and Chemical Biology College of Chemical Engineering, Northeastern University Boston, USA, Aug. 2013 ~ Jan. 2015 B.S. Degree in Polymer Science and Engineering College of Engineering, Jilin University Changchun, China, Sep. 2009 ~ Jul. 2013 B.S. Degree in Actuarial Sciences College of Mathematics, Jilin University Changchun, China, Sep. 2010 ~ Jul. 2013

Research Experiences

• Senior Scientist
  • Crown Bioscience International, Jun 2020 – Now
  • Cancer Biology&Immunology: R&D for PDXO/PDO and Study Director
  • Design and perform experiments to uncover novel mechanisms
  • Assure the scientific, administrative and regulatory aspects of the study are controlled
  • Coordinating the inputs of project manager, scientific/technical staff and the QAU
  • Study plan design/approval, as well as overseeing data collection, analysis and reporting
  • Responsible for communication with clients during the project
  • Technique support to projects and other tasks
• Research Associate
  • Boston Children Hospital and Harvard Medical School, Boston, MA, Sep 2019 - Aug 2020
  • Three-dimensional single cell patterning for high-throughput studies of tumor cell and extracellular matrix heterogeneity
  • Confocal microscopy image analysis
• Interdisciplinary Research Assistant Intern
  • MIT Media Lab, Cambridge, MA, May 2019 – Aug 2019
  • Machine learning models for predicting drug approvals and clinical-Phase transitions
  • Using clinical trial data to personalize treatment decisions
  • Using data science to forecast clinical trial outcomes
• Senior Scientist Intern
  • Bristol Myers Squibb, Boston, MA, Aug 2018 – May 2019
  • In-vitro group (upstream): CR, TCA, HE(CRO); In-vivo: PDX/CDX in-vivo task, immunology therapy
• Analytical Separations Engineer Intern
  • Catabasis Pharmaceuticals Inc., Cambridge, MA, May 2017 – Oct 2017
  • Guide project DMPK activities across multiple phases, including lead discovery, lead optimization and regulatory filings
• Research Associate
  • Harvard Medical School, Boston, MA, Jan 2015 – Aug 2018
  • Optimization Analytics, Data Analysis, Operations research
• Research Assistant at Department of Biomedical Engineering
  • Northeastern University, Boston, MA, Apr 2013 – Aug 2018
  • 3D microtissues as in vitro model for personalized radiation therapy
  • Researching 3D microtissue assay for high-throughput cytotoxicity of nanoparticles
  • Designed multi-marker based blood assay for rapid reliable screening of diseases

Publications

Papers

1. Yuting Qiu, Ming Su. In-vitro three dimensional spheriods for personalized radiation therapy. Dissertation.
2. Yuting Qiu, Lili Xi, Xun Shi, Pengfei Qiu, Wenqing Zhang, Lidong Chen, James R Salvador, Jung Y Cho, Jihui Yang, Yuan-chun Chien, Sinn-wen Chen, Yinglu Tang, G Jeffrey Snyder. Charge-compensated compound defects in Ga-containing thermoelectric skutterudites, Advanced Functional Materials, 2013, 23, 3194-3203.
3. Yuting Qiu, Juanjuan Xing, Xiang Gao, Lili Xi, Xun Shi, Hui Gu, Lidong Chen. Electrical properties and microcosmic study on compound defects in Ga-containing thermoelectric skutterudites, Journal of Materials Chemistry A, 2014, 2, 10952-10959.
4. Yuting Qiu, Liyuan Ma, Xiaojie, Xun, Thomas J. Webster, Ming Su. Enhancing radiation therapy with cell penetrating peptide modified gold nanoparticles, Austin Journal of Biomedical Engineering, 2016, 3, 1033.
5. Y. Qiu, D. Ning, P. Zhang, S. Curly, Y. Qiao, L. Ma, M. Su, Three-dimensional micro-tissues as in vitro model for personalized radiation therapy, Analyst 2017, 142, 3605., as front cover article.
6. Qiu YT, Zheng LY, Ng SK, Ma LY, Su M. Nanoparticle enhanced anti-metastatic treatment of cancer with ionizing radiation, accepted by Journal of Materials Science: Materials in Medicine, 2019.
7. Qiu, Y.T., Yamaguchi, S., Nagamune, T., Su, M. Photo controlled micropatterning of 3D microtissues for radiation assessment, accepted by ACS Omega, 2019.
8. Y. Qiu, J. Li, L. Ma, M. Su. Enhanced cell proliferation on nanocellulose hydrogel film modified substrate, submitted to Biomaterials.
9. Yinglu Tang, Yuting Qiu, Lili Xi, Xun Shi, Wenqing Zhang, Lidong Chen, Ssu-Ming Tseng, Sinn-wen Chen, G Jeffrey Snyder. Phase diagram of In–Co–Sb system and thermoelectric properties of In-containing skutterudites, Energy & Environmental Science, 2014, 7, 812-819.
10. J. Xia, Y. Qiu, X. Xun, L. Ma, J. Guan, M. Su, Single cell patterning for high throughput sub-cellular toxicity assay, Analytica Chemica Acta 2018, 1007, 26.
11. Q. Li, Y. Qiu, L. Ma, M. Su, Single identical cell toxicity assay on coordinately ordered patterns, Analytica Chimica Acta 2019, 1065, 56.
12. Xiaobo Chen, Yuting Qiu, Zhenzhen Song, Qi-Xiang Li, Sheng Guo. Authentication, characterization and contamination detection of cell lines, xenografts and organoids by barcode deep NGS sequencing, NAR Genomics and Bioinformatics 2020, 2, 3.
13. Hongjuan Zhang, Jun Zhou, Yuting Qiu, Jia Zheng, Limei Shang, Chunmei Li, Xuefei Yan, Rui Zhang, Mingfa Zang, Annie Xiaoyu An, Xiaoxi Xu, Shuzong Wang, Henry Li, Yujun Huang. Tumor organoid and immune cell co-culture system potentiates immuno-oncology drug development, J Immunother Cancer 2020, 10, 1136.
14. X. Xu, Y. Qiu, P. Wang, J. Zhou, X. Ouyang, M. Zheng, B. Mao, L. Zhang, B. Chen, J. Wang, J. Chen, W. Qian, S. Guo, Y. Huang, Q. Li. Creating Matched In vivo/In vitro Patient-Derived Model Pairs of PDX and PDX-Derived Organoids for Cancer Pharmacology Research, JoVE 2021.
15. Xiaoxi Xu, Yuting Qiu, Lili Wang, Chunmei Li, Yan Liu, Peng Han, Zhongman Sun, Yaping Qu, Likun Zhang, Bonnie Chen, Davy Ouyang, Yujun Huang, Henry Li. Establishing a Large Tumour Organoid Biobank using a WellCharacterised/Annotated Patient-Derived Xenograft (PDX) Library to Enable Drug Discovery and Translational Research, Crown Bioscience Inc.

Patents

• Ming Su, Junfei Xia, Yuting Qiu. Single Cell Patterning for High Throughput Toxicity Assay 5200.2185-000 (INV-18025)

Professional Experience

• Three-Dimensional microtissue assay for high-throughput cytotoxicity of nanoparticles
  • Three-dimensional microtissue cell culture.
  • Studied radiation damage to cells using a variety of techniques with different end points.
  • Examined the damage to cell membranes and reduction in metabolic activity.
  • Designed multi-marker-based blood assay for rapid reliable screening of diseases.
• Liver S9 fraction assay as a screen for metabolic stability
  • Identified intracellular enzyme(s) responsible for drug metabolism of the compounds synthesized using SMART linker technology platform.
  • Compared the data from the three systems and present the results.
• Enhanced cancer radiation therapy with cell penetrating peptide modified gold nanoparticles
  • Synthesized cell penetrating peptide modified gold nanoparticles.
  • Detected cellular and genetic damage in cancer cells using bright field imaging, MTT, DNA damage, reactive oxygen species and immunofluorescence.
• Nanoparticle enhanced anti-metastatic treatment of cancer with ionizing radiation
  • Enhanced the anti-metastatic effect of ionizing X-ray radiation.
• Nanocellulose hydrogel as 3D scaffold for tissue engineering
  • Generated single cell cluster array.
  • Detected 3D cluster migration speed in different thickness of alginate gel.
  • Researched 3D cluster model in drug delivery system.
• Single cell patterning for high throughput sub-cellular toxicity assay
  • Generated single cell array.
  • Obtained simultaneously cell responses at population level, single cell level and sub-cellular level at high throughput.
  • Determined the expressions of proteins associated with cell migration and invasion, and production of reactive oxygen species (ROS) using two image processing software written in Python and MATLAB.
• Self-Etching of metal–organic framework templates during polydopamine coating
  • Researched about synthesis of micro and nanostructure functional materials.
  • Designed, synthesized, and evaluated nanomaterials for various medical applications, including self-assembled chemistries and nanostructured materials.
• 3D microtissue personalization of treatment decisions for cancer patients
  • Medical imaging technologies using unorthodox artificial intelligence for early disease diagnoses
  • Novel ethical, secure and explainable artificial intelligence based digital medicines and treatments
  • Point-of-care medical technologies for real world data and evidence generation to improve public health
• Microtissues and microfluidic technology for multi-tissue experiments and analysis
  • Microfluidic device and setup
  • Microfluidic bio-activation and effect of cyclophosphamide
• Established a large tumor organoid biobank using a well-characterised patient-derived xenograft library to enable drug discovery and translational research
  • PDXO establishment, characterisation, and biobanking scheme.
  • Established >100 PDXOs covering >10 cancer types, including bladder, breast, colorectal, gastric, liver, lung, ovarian, and pancreatic cancer, cholangiocarcinoma, etc.
  • Created a unique library of matched in vitro/in vivo models with high translational power and enabling HTS, cellular/structural similarities between PDXO and the original PDX, tissue specific structural features are maintained in the 3D organoids.
  • Mathematical models of authentication, characterization and contamination detection of organoids by barcode deep NGS sequencing.
• Creating matched in vivo/in vitro patient-derived model pairs of PDX and PDX-derived organoids for cancer pharmacology research
  • Created organoids using PDX for in vitro screening, resulting in matched pairs of in vivo/in vitro models.
  • Tumor organoid and immune cell co-culture system potentiates immuno-oncology drug development.
  • In-vitro liver system: application in drug metabolism and pharmacokinetics and toxicology.

Awards and Honors

• AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA, 2020.
• MGH CSSA Volunteer Award, 2019.
• Best Poster in MRS, Boston, MA, 2018.
• One article published in Analyst was selected as a front cover, 2017.
• Outstanding Graduate Researcher, Department of Chemical Engineering, 2017.
• Best Poster in BMES, Minneapolis, MN, 2016.
• The 3rd Grade Award, College of Engineering, Jilin University, 2013.
• Excellent Student, College of Chemistry, Jilin University, 2013.
• The 3rd Class Freshman Scholarship, Jilin University, 2011.

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